CDC researchers have developed technology that consists of a simple and inexpensive technique for creating fluorescent labeled primers for nucleic acid amplification. Fluorescent chemical-labeled probes and primers are extensively used in clinical and research laboratories for rapid, real-time detection and identification of microbes and genetic sequences. During nucleic acid amplification, the "UniFluor" primer is incorporated into newly synthesized double stranded DNA.
Inventor First Name:
Jothikumar
Vincent
Inventor Last Name:
Narayanan
Hill
E Number Only:
E-252-2013
Inv Is lead:
Pat Filing Date:
2006-01-03
2006-01-03
2005-01-03
2006-01-03
Patent Issue Date:
2010-05-04
Patent Number:
7,709,626
Provider Technology ID:
2741
Patent Application:
11/325,270
PCT/US2006/000175
60/641,303
12/267,869
LPM Zip:
20892-9804
LPM Organization:
NIH Office of Technology Transfer
LPM Phone:
301-443-8518
LPM State:
MD
- Bioinformatics
- Gene-based
- Platform
Updated On:
Monday, March 9, 2020
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Related Patent Publish Date:
Monday, August 6, 2012
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Wednesday, February 4, 2015
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Wednesday, August 3, 2005
Thursday, August 3, 2006
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Related Invention:
E-273-2013-0
E-292-2013-0
E-458-2013-0
Related Patent Application:
PCT/US2012/049784
PCT/US2008/084347
12/743,607
60/989,768
14/419,641
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LPM Last Name:
Mitzelfelt
LPM FIrst Name:
Jeremiah
Development Stage:
Date Published:
Monday, March 9, 2020
Development Status:
In vitro data available
DTDT Classification:
Devices/Instruments; Software; Mfg Technology/Methods; Research Tools & Material
Diagnostics
Methods
Research Tools and Materials
Instruments (e.g. spectrometers, microscopes)
Methods of Using Research Tools
Biologicals and Chemicals
Arthritis
Biodefense Related
Cancer
Cardiovascular Disease
Central Nervous System
Diabetes
Endocrine
Hyperlipidemia
Hypertension
Infectious Diseases (bacterial)
Infectious Diseases (fungal)
Infectious Diseases (viral)
Pain
Psychiatry
Zoonotic/Veterinary
Others
Biodefense
Diagnostic
Environmental Sampling, Testing
Monitoring (Public Health/Counterfeit Detection/Biological)
Research Tool
Bioinformatics
Gene-based
Platform
In vitro data available
DTDT Description:
Devices/Instrumentation
Devices/Instrumentation - Diagnostics
Devices/Instrumentation - Diagnostics: Methods
Devices/Instrumentation - Research Tools and Materials
Devices/Instrumentation - Research Tools and Materials: Instruments
Devices/Instrumentation - Research Tools and Materials: Methods of Using Research Tools
Devices/Instrumentation - Research Tools and Materials: Biologicals and Chemicals
Arthritis
Biodefense Related
Cancer
Cardiovascular Disease
Central Nervous System
Diabetes
Endocrine
Hyperlipidemia
Hypertension
Infectious Diseases (bacterial)
Infectious Diseases (fungal)
Infectious Diseases (viral)
Pain
Psychiatry
Zoonotic/Veterinary
Others
Biodefense
Diagnostic
Applications - Environmental Sampling/Testing
Monitoring (Public Health/Counterfeit Detection/Biological)
Research Tool
Bioinformatics
Gene-based
Platform
In vitro data available
Collaboration Sought:
Yes
Additional Patents:
Several international patent applications pending or issued
Advantages:
- Simple to implement
- Rapid, real-time detection
- Used with standard laboratory equipment capable of monitoring fluorescence-intensity shifts
- Cost-effective
- Easily adapted for use in kits or arrays
Application:
Monitoring
(Public Health/Counterfeit Detection/Biological)
Applications:
- Quantitative detection and/or amplification of specified nucleic acid sequences
- Efficient fluorescence-labeling of oligonucleotides
- Pyro-sequencing
- Basic laboratory research
NIH Ref. No.:
E-252-2013-0
IC:
CDC
LPM Address:
BG 5601FL RM 2G29 MSC 9804
5601 FISHERS LN
Inventor Lab URL:
https://www.cdc.gov/media/spokesperson/
LPM City:
Bethesda
LPM Email:
jeremiah.mitzelfelt@nih.gov
Inventor IC:
CDC
CDC
Institute or Center:
Lead Inventor:
Disease Area: